Accelerated Cardiac Differentiation of Induced Pluripotent Stem Cells by Electrical Stimulation

 

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Technology Overview

Dr. Wang and his team at the University of Cincinnati have developed a method for the accelerated differentiation of iPSCs into cardiac cells through electrical stimulation. By avoiding the need to add certain exogenous growth factors, this method is less expensive, more reproducible, and more scalable than standard methods currently in use.

Background

Stem cells are pluripotent cells with remarkable potential to develop into many different cell types in the body during early life and growth. Stem cells hold promise for regenerative medicine and cell therapy, especially in fields where more personalized medicine approaches are becoming increasingly predominant. For example, a wide variety of progenitor/stem cell therapies are recognized as a promising strategy to repair damaged tissue, such as an ischemic damaged heart. Although stem cells carry promise, there are still challenges. Current protocols for differentiating induced pluripotent stem cells (iPSCs) into mature cardiomyocytes are expensive, poorly reproducible, and limited in terms of scale-up.

Advantages and Benefits
  • Faster generation of Cardiac Cells
  • More reproducible results compared to standard methods
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Patents
Serial No. File Date Patent No. Issued Date
14/995,997 1/14/2016 9,868,938 1/16/2018
15/837,366 12/11/2017 10,513,688 12/24/2019
Other Media
Inventor(s)
  • Ruilian Ma
  • Ha Won Kim
  • Yi-Gang Wang
Contact
Rucha Tadwalkar
Licensing Associate
Lead Inventor